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KMID : 1201420150080020126
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Journal of Neurocritical Care
2015 Volume.8 No. 2 p.126 ~ p.129
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Paraneoplastic Brainstem Encephalitis Associated with Anti-Hu Antibody
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Yoon Jee-Eun
Lee Kyung-Bok
Kim Ji-Sun
Ahn Moo-Young
Roh Hak-Jae
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Abstract
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Background: Background: Paraneoplastic brainstem encephalitis (PBE) is a rare syndrome and has been described in patients with lung and breast cancer. Several anti-neuronal nuclear antibodies are associated with PBE.
Case Report: We experienced a case of a 79-year-old man who suddenly developed memory loss, diplopia and cerebellar ataxia. Brain magnetic resonance imaging (MRI) revealed high signal intensity in midbrain, pons and middle cerebellar peduncle on T2-weighted and fluid attenuation inversion recovery (FLAIR) images. Chest computed tomography (CT) revealed a lung mass ; and serum tests were positive for anti-Hu antibody. The patient was unresponsive to all treatments including immunotherapy.
Conclusion: We reported a patient with acute-onset of PBE with anti-Hu antibody. Anti-Hu antibody associated brainstem encephalitis is usually non-responsive to immunotherapy. Earlier diagnosis and treatment are a challenge for improving the prognosis of paraneoplastic brainstem encephalitis.
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KEYWORD
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Paraneoplastic brainstem encephalitis, Lung cancer, Anti-Hu antibody
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